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SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.9
USERS' SCORE
Good
Based on 11 Reviews
8.8
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B6 (as Pyridoxal-5-Phosphate)
1.5 mg
88%
Folate (400 mcg as (6S)-5-MTHF [from (6S)-5-Methyltetrahydrofolate Glucosamine Salt])
680 mcg DFE‡
170%
Vitamin B12 (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
9
Folic acid impacts blood clotting
Folic acid targets splenic extramedullary hemopoiesis to attenuate carbon black-induced coagulation-thrombosis potential.
Significant relevance to folate's effects
We investigated how folic acid affects blood clotting, particularly when exposed to carbon black (CB), a common industrial substance. In our study with adult C57BL/6 mice, we found that prolonged exposure to CB led to increased blood clotting potential due to changes in the spleen, where extra blood cell production occurs.
Notably, we observed that CB exposure caused an increase in certain cells responsible for blood clotting, while decreasing folic acid levels in the bloodstream. This drop in folic acid seemed to correlate with heightened levels of prostaglandin E2, a compound that can drive inflammation and increase blood clotting.
When we supplemented the mice with folic acid, we noted a reduction in the negative effects of CB on blood clotting. This protective effect appeared to stem from folic acid's ability to inhibit the enzymes involved in the excessive production of prostaglandins by splenic macrophages. Overall, our findings suggest that folic acid supplementation could be a valuable strategy to mitigate the heightened risk of thrombosis associated with carbon black exposure.
Notably, we observed that CB exposure caused an increase in certain cells responsible for blood clotting, while decreasing folic acid levels in the bloodstream. This drop in folic acid seemed to correlate with heightened levels of prostaglandin E2, a compound that can drive inflammation and increase blood clotting.
When we supplemented the mice with folic acid, we noted a reduction in the negative effects of CB on blood clotting. This protective effect appeared to stem from folic acid's ability to inhibit the enzymes involved in the excessive production of prostaglandins by splenic macrophages. Overall, our findings suggest that folic acid supplementation could be a valuable strategy to mitigate the heightened risk of thrombosis associated with carbon black exposure.
Read More
8
Pediatric blood clot management insights
CENTRAL RETINAL VEIN OCCLUSION IN 12-YEAR-OLD GIRL WITH METHYLENETETRAHYDROFOLATE REDUCTASE MUTATION: A CASE REPORT AND REVIEW OF THE LITERATURE.
Research indicates folate's role
We examined the case of a healthy 12-year-old girl who experienced a central retinal vein occlusion. This incident was particularly notable because she later developed retinal neovascularization at the age of 24. This timing marks the longest gap reported between such a pediatric event and subsequent complications.
Throughout the evaluation, we noted that the girl's family history was not significant for similar conditions. However, laboratory tests flagged a mildly elevated homocysteine level and uncovered a homozygous C677T mutation in methylenetetrahydrofolate reductase. As a proactive measure, we initiated folate supplementation to possibly mitigate future thrombotic risks.
So far, this approach has shown promise, as the patient has not experienced further ocular or systemic clotting issues. Our findings suggest that folate supplementation may play a beneficial role in managing elevated homocysteine levels, which are associated with blood clotting complications.
This case highlights the importance of a thorough systemic workup and the necessity for long-term follow-up in pediatric patients with central retinal vein occlusion. By taking measures like folate supplementation, we aim to prevent serious complications such as intraocular hemorrhage and neovascular glaucoma.
Throughout the evaluation, we noted that the girl's family history was not significant for similar conditions. However, laboratory tests flagged a mildly elevated homocysteine level and uncovered a homozygous C677T mutation in methylenetetrahydrofolate reductase. As a proactive measure, we initiated folate supplementation to possibly mitigate future thrombotic risks.
So far, this approach has shown promise, as the patient has not experienced further ocular or systemic clotting issues. Our findings suggest that folate supplementation may play a beneficial role in managing elevated homocysteine levels, which are associated with blood clotting complications.
This case highlights the importance of a thorough systemic workup and the necessity for long-term follow-up in pediatric patients with central retinal vein occlusion. By taking measures like folate supplementation, we aim to prevent serious complications such as intraocular hemorrhage and neovascular glaucoma.
Read More
8
Folate's role in blood health
Cystoid Macular Edema Associated With Venous Stasis in a Patient With Previously Undiagnosed Hyperhomocysteinemia.
Explores hyperhomocysteinemia treatment
We observed a 74-year-old female patient who sought help for unilateral vision reduction attributed to cystoid macular edema and retinal venous stasis. During our examination, we noted her visual acuity was reduced in the affected left eye. Further investigation through imaging techniques confirmed her diagnosis and revealed systemic issues related to elevated homocysteine levels.
The relationship between homocysteine and vascular complications made us consider hyperhomocysteinemia as a significant risk factor for her condition. We were particularly interested in how addressing her elevated homocysteine with folate—commonly known for its role in blood health—could impact her treatment.
The patient was treated with anti-vascular endothelial growth factor (VEGF) injections and prescribed oral folic acid for life to manage her condition. We were pleased to see her vision improve significantly and maintain stability for an extended period. However, when cystoid macular edema returned, she received additional intravitreal injections, indicating ongoing vigilance was necessary.
Ultimately, our findings suggest that while folate may contribute positively to managing blood clot risks, particularly in the context of hyperhomocysteinemia, its effects can be complicated by the combined treatment of anti-VEGF injections, highlighting the complexity of such cases.
The relationship between homocysteine and vascular complications made us consider hyperhomocysteinemia as a significant risk factor for her condition. We were particularly interested in how addressing her elevated homocysteine with folate—commonly known for its role in blood health—could impact her treatment.
The patient was treated with anti-vascular endothelial growth factor (VEGF) injections and prescribed oral folic acid for life to manage her condition. We were pleased to see her vision improve significantly and maintain stability for an extended period. However, when cystoid macular edema returned, she received additional intravitreal injections, indicating ongoing vigilance was necessary.
Ultimately, our findings suggest that while folate may contribute positively to managing blood clot risks, particularly in the context of hyperhomocysteinemia, its effects can be complicated by the combined treatment of anti-VEGF injections, highlighting the complexity of such cases.
Read More
Most Useful Reviews
9.5
Reduced blood clot
I switched to this more affordable complex to lower my homocysteine, which is harmful to blood vessels and can cause blood clots. After taking it, my levels went down from 9.3 to 5.5. I'll continue using it, particularly since it’s essential for girls planning pregnancy.
Read More
9.5
Normalised blood clot
My husband, who has type 2 diabetes, experienced a drop in vitamins while on medication. He takes this supplement and his blood counts have normalised, along with lower homocysteine levels. It’s effective and necessary for diabetes and blood clots. I highly recommend it!
Read More
9.5
Blood clot decreased
I began taking this supplement to lower my homocysteine, which was previously high. After two months, my levels dropped significantly, indicating its effectiveness. I’m continuing with a lower dosage and am pleased with the results concerning blood clots.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.9
9.5
High homocysteine management strategy
Treatable high homocysteine alone or in concert with five other thrombophilias in 1014 patients with thrombotic events.
Vitamins show potential benefits
We explored the effects of high serum homocysteine levels on blood clot risks within a group of 1,014 patients who experienced thrombotic events. This group underwent a thorough evaluation for various thrombophilic conditions. Notably, we found that 12% of these patients had treatable high homocysteine levels.
Among those with high homocysteine, we examined a treatment regimen that included vitamin B6, alongside L-methyl folate and vitamin B12. After approximately 18 months of this combined treatment, we observed significant reductions in homocysteine levels, with many patients reaching normal levels.
Importantly, when high homocysteine was the only identified thrombophilia, those who achieved normalization of their homocysteine levels reported a remarkable decrease in new thrombotic events. Thus, while vitamin B6 plays a role in lowering homocysteine, its specific isolated impact on blood clotting remains unclear as part of the combined therapy.
Overall, our findings highlight the relevance of managing high homocysteine through vitamin treatment to potentially lower the risk of blood clots, especially in individuals with no other identified thrombophilia.
Among those with high homocysteine, we examined a treatment regimen that included vitamin B6, alongside L-methyl folate and vitamin B12. After approximately 18 months of this combined treatment, we observed significant reductions in homocysteine levels, with many patients reaching normal levels.
Importantly, when high homocysteine was the only identified thrombophilia, those who achieved normalization of their homocysteine levels reported a remarkable decrease in new thrombotic events. Thus, while vitamin B6 plays a role in lowering homocysteine, its specific isolated impact on blood clotting remains unclear as part of the combined therapy.
Overall, our findings highlight the relevance of managing high homocysteine through vitamin treatment to potentially lower the risk of blood clots, especially in individuals with no other identified thrombophilia.
Read More
9
Vitamin B6 in CVST treatment
Cerebral Venous Sinus Thrombosis Secondary to Vitamin B12 Deficiency - A Case Series with Emphasis on Food Fortification.
Study limits isolated B6 effects
We explored the connection between vitamin levels and cerebral venous sinus thrombosis (CVST), particularly focusing on vitamin B6. Our case series documented three instances of CVST where patients presented with headaches, and two experienced additional symptoms like visual disturbances.
In our findings, we noted that two of these patients had notably low levels of vitamin B12, alongside the presence of hyperhomocysteinemia (hHcy). Treatment included low-molecular-weight heparin and supplements of vitamins B6, B9, and B12.
While vitamin B6 was used as part of the supplementation strategy, the specific impact of vitamin B6 alone on blood clotting wasn't thoroughly isolated in this study. All patients showed positive responses to the treatment, with follow-up imaging indicating resolution of the thrombosis in two cases.
This suggests that addressing vitamin deficiencies, particularly in those on vegetarian diets, is vital. Nevertheless, further dedicated research is necessary to determine the isolated effect of vitamin B6 on blood clots.
In our findings, we noted that two of these patients had notably low levels of vitamin B12, alongside the presence of hyperhomocysteinemia (hHcy). Treatment included low-molecular-weight heparin and supplements of vitamins B6, B9, and B12.
While vitamin B6 was used as part of the supplementation strategy, the specific impact of vitamin B6 alone on blood clotting wasn't thoroughly isolated in this study. All patients showed positive responses to the treatment, with follow-up imaging indicating resolution of the thrombosis in two cases.
This suggests that addressing vitamin deficiencies, particularly in those on vegetarian diets, is vital. Nevertheless, further dedicated research is necessary to determine the isolated effect of vitamin B6 on blood clots.
Read More
9
Homocystinuria treatment with B6
Cerebral venous thrombosis as the first presentation of classical homocystinuria in an adult patient.
Significant, vitamin B6's role noted
We explored the intriguing case of a 30-year-old woman who experienced severe headaches and neurological symptoms, later linked to blood clotting issues. Initially diagnosed with suspected viral encephalopathy, she faced multiple health challenges including a pulmonary embolism and persistent migraines.
After undergoing various investigations, her doctors discovered she had a dangerously high homocysteine level of over 350 μmol/L, indicating a metabolic disorder known as homocystinuria due to cystathionine β-synthase deficiency. This condition is typically identified in childhood, making her case particularly unusual.
To tackle her elevated homocysteine, a treatment plan involving vitamin B6 (pyridoxine) and betaine was implemented. Remarkably, this approach successfully normalized her homocysteine levels, and she has since avoided any further thrombotic events. Though vitamin B6 is a key player in her treatment, it was administered alongside betaine, which complicates isolating the effects of B6 on blood clot prevention alone.
After undergoing various investigations, her doctors discovered she had a dangerously high homocysteine level of over 350 μmol/L, indicating a metabolic disorder known as homocystinuria due to cystathionine β-synthase deficiency. This condition is typically identified in childhood, making her case particularly unusual.
To tackle her elevated homocysteine, a treatment plan involving vitamin B6 (pyridoxine) and betaine was implemented. Remarkably, this approach successfully normalized her homocysteine levels, and she has since avoided any further thrombotic events. Though vitamin B6 is a key player in her treatment, it was administered alongside betaine, which complicates isolating the effects of B6 on blood clot prevention alone.
Read More
9
Folate's role in thrombosis treatment
Cerebral venous thrombosis with hyperhomocysteinemia due to loss of heterozygosity at methylenetetrahydrofolate reductase (MTHFR) locus: a case report.
Moderately relevant case findings
We observed a fascinating case involving a 14-year-old girl who experienced severe headaches and nausea, leading to the discovery of cerebral venous thrombosis (CVT) and significantly elevated plasma homocysteine levels. Through comprehensive genetic testing, we identified a rare genetic change called loss of heterozygosity (LOH) affecting the methylenetetrahydrofolate reductase (MTHFR) gene, which plays a crucial role in processing folate in the body.
In treating the patient, we included supplementary folate along with anticoagulants to manage the thrombosis. While we noted improvements in her symptoms and a decrease in thrombosis severity, it is essential to recognize that the isolated effect of folate on blood clotting cannot be fully established due to the concurrent use of anticoagulants and other vitamin supplements. Therefore, while folate forms part of the treatment, its direct impact on clot formation requires further investigation.
The combination of anticoagulants, nutritional supplements, and genetic insights showcases an integrated approach to managing complex medical issues, highlighting that while folate is beneficial, its role is part of a broader strategy.
In treating the patient, we included supplementary folate along with anticoagulants to manage the thrombosis. While we noted improvements in her symptoms and a decrease in thrombosis severity, it is essential to recognize that the isolated effect of folate on blood clotting cannot be fully established due to the concurrent use of anticoagulants and other vitamin supplements. Therefore, while folate forms part of the treatment, its direct impact on clot formation requires further investigation.
The combination of anticoagulants, nutritional supplements, and genetic insights showcases an integrated approach to managing complex medical issues, highlighting that while folate is beneficial, its role is part of a broader strategy.
Read More
9
Folic acid impacts blood clotting
Folic acid targets splenic extramedullary hemopoiesis to attenuate carbon black-induced coagulation-thrombosis potential.
Significant relevance to folate's effects
We investigated how folic acid affects blood clotting, particularly when exposed to carbon black (CB), a common industrial substance. In our study with adult C57BL/6 mice, we found that prolonged exposure to CB led to increased blood clotting potential due to changes in the spleen, where extra blood cell production occurs.
Notably, we observed that CB exposure caused an increase in certain cells responsible for blood clotting, while decreasing folic acid levels in the bloodstream. This drop in folic acid seemed to correlate with heightened levels of prostaglandin E2, a compound that can drive inflammation and increase blood clotting.
When we supplemented the mice with folic acid, we noted a reduction in the negative effects of CB on blood clotting. This protective effect appeared to stem from folic acid's ability to inhibit the enzymes involved in the excessive production of prostaglandins by splenic macrophages. Overall, our findings suggest that folic acid supplementation could be a valuable strategy to mitigate the heightened risk of thrombosis associated with carbon black exposure.
Notably, we observed that CB exposure caused an increase in certain cells responsible for blood clotting, while decreasing folic acid levels in the bloodstream. This drop in folic acid seemed to correlate with heightened levels of prostaglandin E2, a compound that can drive inflammation and increase blood clotting.
When we supplemented the mice with folic acid, we noted a reduction in the negative effects of CB on blood clotting. This protective effect appeared to stem from folic acid's ability to inhibit the enzymes involved in the excessive production of prostaglandins by splenic macrophages. Overall, our findings suggest that folic acid supplementation could be a valuable strategy to mitigate the heightened risk of thrombosis associated with carbon black exposure.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.8
9.5
Blood clot improvement
I take this for my son with ADHD. Recommended by our neurologist, it has improved his blood counts and lowered homocysteine. My son dissolves the tablets easily due to their pleasant taste. We are satisfied with this supplement.
9.5
Reduced blood clot
I switched to this more affordable complex to lower my homocysteine, which is harmful to blood vessels and can cause blood clots. After taking it, my levels went down from 9.3 to 5.5. I'll continue using it, particularly since it’s essential for girls planning pregnancy.
9.5
Normalised blood clot
My husband, who has type 2 diabetes, experienced a drop in vitamins while on medication. He takes this supplement and his blood counts have normalised, along with lower homocysteine levels. It’s effective and necessary for diabetes and blood clots. I highly recommend it!
9.5
Blood clot decreased
I began taking this supplement to lower my homocysteine, which was previously high. After two months, my levels dropped significantly, indicating its effectiveness. I’m continuing with a lower dosage and am pleased with the results concerning blood clots.
8.8
Improved blood clot
Super! I take this supplement periodically to correct my anemia and low cholesterol. It's very effective; my tests showed a deficiency in B12 and B9, leading to lower haemoglobin. After taking this, my performance improved along with my lipid profile. I am confident this supplement significantly contributed to my results, which physical activity and diet couldn't achieve alone.
Read More
